Replace your media cermic rings ocassionally. Your best bet to keep the besificial bacteria in your nano cube aquarim or tank to to alt weeks and replace a differnet week than you replace other items like carbon and sponges or bio balls though.
If you replace all of your media you will lose to much good bacteria!!
Ceramic Rings for the jbj nano cube are ideal for fostering benificial bacteria. Your fish will appreciate this.